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Cardiac Applications

Power for your heart

Cardiac magnetic resonance (CMR) imaging is the gold standard for visualizing myocardial pathologies such as infarction, myocarditis, and cardiomyopathies. It’s proven to be reliable for determining infarct size, tissue perfusion, and contractility, impacting prognosis significantly. CMR also assesses myocardial viability post-infarction and stages cardiomyopathies.

Research is focusing on pre-infarction myocardial tissue assessment in coronary heart disease (CHD) patients. By increasing heart rate with drugs like dobutamine and adenosine, CMR evaluates myocardial perfusion under stress. This helps detect impairments indicating coronary artery stenosis.

CHD, combined with cardiovascular risk factors and reduced activity, affects myocardial mitochondrial function, potentially leading to myocardial infarction. Stress CMR measures contractility, perfusion, and late enhancement to assess exercise-induced myocardial ischemia. However, drug-induced stress can have complications, unlike physiologic stress from ergometer use.

Ergospect GmbH specializes in high-level ergometers for MR scanner compatibility, facilitating investigations during constant workload. Unlike other ergometers, ours support exercise testing within the MR scanner.

Postoperative monitoring of congenital heart defect patients involves assessing ventricular hypertrophy and circulation impairments. Our devices enable realistic assessments under workload, vital for understanding circulation impairments accurately.

Therefore, employing our devices yields the following benefits:
  • Mitigate risks associated with drug-induced stress CMR.
  • Mimic physiological workloads encountered in daily activities.
  • Enhance diagnostic accuracy for prognostic assessment of CHD patients.
  • Evaluate reserve capacity in patients with cardiomyopathies.
  • Visualize postoperative circulation issues in congenital heart defect patients.
Application Fields of the Cardiac Module

Functional Specification:

  • stress MRI of heart and circulation, cerebral blood flow

Indications:

  • coronary heart disease (CHD), myocardial infarction (MI)
  • arrhythmogenic right ventricular cardiomyopathy (ARVD)
  • heart failure with preserved ejection fraction (HFpEF)
  • congenital heart diseases before and after treatment
  • evaluation of morphologic and functional changes in hearts of sports men and patients
  • evaluation of aortic (e.g. aortic aneurysms, aortic coarctation), coronary arterial, pulmonary and cerebral blood flow during exercise
  • assessment of endothelial function of aorta, coronary arteries and internal mammary artery (IMA) during exercise with and without application of vasodilators
  • investigation of heartmuscle metabolism of patients, athletes and amateur sportsmen
  • evaluation of the effects of aerobic exercise on ventricular remodelling in patients (MI)
  • assessment of training progress in patients (e.g. chronic obstructive pulmonary disease (COPD), peripheral arterial disease (PAD), chronic heart failure), athletes and amateur sports men
  • exercise responses to gravity-independent training

Parameters:

  • 31P MRS, 13C MRS: determination of mitochondrial function, anaerobic and aerobic capacity and glycogen metabolism
  • 1H-MRS: lipid metabolism and deoxymyoglobin: tracking of intra- and extra-myocellular lipids and myoglobin
  • Functional MRI (fMRI) of the brain: inversion time (TI) pulsed arterial spin labelling (PASL): measurement of relative CBF before, during and after exercise
  • perfusion MRI: microcirculation within the myocardium or changes in myocardial tissue elasticity
  • phase-contrast MRI: assessment of blood flow
  • CINE MRI: real-time imaging of cardiac action
  • relaxometry: determination of oedema or water content in the myocardium under stress

Target:

  • angiologists, cardiologists, gerontologists, heart surgeons, paediatricians, physiologists, pulmonologists, radiologists, sports physicians, training facilities for astronauts and athletes, vascular physicians/surgeons
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